Harvey R Weiss Selected Research

PF-4708671

4/2024	Inhibition of p70 Ribosomal S6 Kinase (S6K1) Reduces Cortical Blood Flow in a Rat Model of Autism-Tuberous Sclerosis.
10/2020	Lysophosphatidic acid increased infarct size in the early stage of cerebral ischemia-reperfusion with increased BBB permeability.
7/2019	Inhibition of p70 ribosomal S6 kinase 1 (S6K1) by PF-4708671 decreased infarct size in early cerebral ischemia-reperfusion with decreased BBB permeability.

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Harvey R Weiss Research Topics

Disease

31	Brain Ischemia (Cerebral Ischemia) 09/2023 - 04/2002
12	Ischemia 09/2023 - 04/2002
9	Infarction (Infarctions) 09/2023 - 01/2015
7	Myocardial Stunning (Stunned Myocardium) 01/2007 - 05/2002
6	Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome) 09/2023 - 06/2015
5	Autistic Disorder (Autism) 04/2024 - 08/2007
5	Cardiomegaly (Heart Hypertrophy) 07/2010 - 10/2004
5	Hypoxia (Hypoxemia) 07/2010 - 01/2008
4	Hypertrophy 07/2010 - 03/2005
3	Autism Spectrum Disorder 04/2024 - 10/2012
3	Tuberous Sclerosis (Bourneville's Disease) 04/2024 - 10/2012
3	Reperfusion Injury 09/2023 - 01/2021
2	Brain Edema (Cerebral Edema) 01/2017 - 07/2009
1	Intellectual Disability (Idiocy) 04/2024
1	Epilepsy (Aura) 04/2024
1	Stroke (Strokes) 09/2023
1	Brain Injuries (Brain Injury) 09/2023
1	Neoplasms (Cancer) 01/2013
1	Hemorrhage 08/2011
1	Hypotension (Low Blood Pressure) 08/2011
1	Type 2 Diabetes Mellitus (MODY) 09/2010
1	Insulin Resistance 09/2010
1	Heart Failure 08/2006

Drug/Important Bio-Agent (IBA)

10	Cyclic GMPIBA 01/2009 - 08/2002
7	Isoflurane FDA LinkGeneric 01/2021 - 04/2002
6	Nitric Oxide (Nitrogen Monoxide)FDA Link 07/2010 - 05/2002
5	AcidsIBA 09/2023 - 12/2003
5	Oxygen (Dioxygen)IBA 01/2020 - 04/2002
5	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2017 - 12/2005
4	Proteins (Proteins, Gene)FDA Link 01/2021 - 11/2004
4	Sirolimus (Rapamycin)FDA Link 01/2021 - 09/2015
3	PF-4708671IBA 04/2024 - 07/2019
3	Ribosomal Protein S6 Kinases (S6 Kinase)IBA 04/2024 - 07/2019
3	Phosphotransferases (Kinase)IBA 01/2021 - 03/2005
3	N-Methylaspartate (NMDA)IBA 12/2010 - 08/2007
3	Natriuretic PeptidesIBA 07/2010 - 01/2008
3	Protein Kinases (Protein Kinase)IBA 01/2008 - 08/2004
3	Thyroxine (Levothyroxine)FDA LinkGeneric 09/2006 - 10/2004
2	trans-sodium crocetinate (crocetin)IBA 04/2024 - 09/2015
2	Saline SolutionIBA 09/2023 - 08/2011
2	lysophosphatidic acidIBA 10/2020 - 01/2020
2	Anesthetics (Anesthetic Agents)IBA 05/2017 - 06/2015
2	Pentobarbital (Nembutal)FDA Link 05/2017 - 06/2015
2	TOR Serine-Threonine KinasesIBA 01/2016 - 09/2015
2	Dexmedetomidine FDA Link 01/2015 - 08/2011
2	propionic acid (potassium propionate)IBA 10/2012 - 07/2009
2	AMPA Receptors (AMPA Receptor)IBA 10/2012 - 12/2010
2	Neurotransmitter Agents (Neurotransmitter)IBA 02/2011 - 07/2009
2	gamma-Aminobutyric Acid (GABA)IBA 02/2011 - 08/2008
2	Deferoxamine (Desferal)FDA LinkGeneric 09/2009 - 04/2008
2	Brain Natriuretic Peptide (Natrecor)FDA Link 01/2007 - 09/2006
2	Nitric Oxide Synthase (NO Synthase)IBA 12/2005 - 05/2002
2	LeptinIBA 06/2005 - 11/2003
2	Metabotropic Glutamate Receptors (Metabotropic Glutamate Receptor)IBA 10/2004 - 12/2003
1	Branched-Chain Amino AcidsIBA 09/2023
1	Proto-Oncogene Proteins c-akt (Protein Kinase B)IBA 09/2023
1	Leucine (L-Leucine)FDA Link 09/2023
1	Ribosomal Protein S6IBA 09/2023
1	Neuroprotective AgentsIBA 09/2021
1	Coloring Agents (Dyes)IBA 01/2021
1	GlucocorticoidsIBA 01/2021
1	2- cyclopentyl- 4- (5- phenyl- 1H- pyrrolo(2,3- b)pyridin- 3- yl)- benzoic acidIBA 01/2021
1	Matrix Metalloproteinase 2 (Gelatinase A)IBA 01/2021
1	Mechanistic Target of Rapamycin Complex 1IBA 01/2021
1	RapaLink-1IBA 01/2021
1	serum-glucocorticoid regulated kinaseIBA 01/2021
1	Mechanistic Target of Rapamycin Complex 2IBA 01/2021
1	Phospholipids (Phosphatides)FDA LinkGeneric 10/2020
1	Nitric Oxide Synthase Type I (Neuronal Nitric Oxide Synthase)IBA 06/2015
1	Hypnotics and Sedatives (Sedatives)IBA 01/2015
1	ThioredoxinsIBA 01/2013
1	1-methylpropyl-2-imidazolyl disulfideIBA 01/2013
1	Antineoplastic Agents (Antineoplastics)IBA 01/2013
1	Cannabinoid Receptor AgonistsIBA 01/2012
1	RimonabantIBA 01/2012
1	(3R)- ((2,3- dihydro- 5- methyl- 3- ((4- morpholinyl)methyl)pyrrolo- (1,2,3- de)- 1,4- benzoxazin- 6- yl)(1- naphthalenyl))methanone (WIN 55,212)IBA 01/2012
1	GABA-A Receptors (GABA(A) Receptor)IBA 02/2011
1	Aminobutyrates (Aminobutyric Acid)IBA 02/2011
1	Ionotropic Glutamate ReceptorsIBA 12/2010
1	selfotelIBA 12/2010
1	2,3- dioxo- 6- nitro- 7- sulfamoylbenzo(f)quinoxaline (NBQX)IBA 12/2010
1	Nonesterified Fatty Acids (NEFA)IBA 09/2010
1	Ciclopirox (Loprox)FDA LinkGeneric 06/2010
1	NitratesIBA 04/2010
1	Opioid Receptors (Opioid Receptor)IBA 01/2010
1	Fentanyl (Sublimaze)FDA LinkGeneric 01/2010
1	mu Opioid Receptors (mu Opioid Receptor)IBA 01/2010
1	Opioid Analgesics (Opioids)IBA 01/2010
1	Excitatory Amino AcidsIBA 07/2009
1	alpha- Amino- 3- hydroxy- 5- methyl- 4- isoxazolepropionic Acid (AMPA)IBA 07/2009
1	Erythropoietin FDA Link 01/2008
1	Protein Kinase InhibitorsIBA 01/2007
1	C-Type Natriuretic Peptide (Peptide, C-Type Natriuretic)IBA 01/2007
1	KT 5823IBA 01/2007
1	Cyclic AMP (AMP, Cyclic)IBA 08/2006
1	8-bromocyclic GMPIBA 08/2006
1	Ryanodine Receptor Calcium Release Channel (Ryanodine Receptor)IBA 05/2006

Therapy/Procedure

5	Anesthesia 01/2021 - 06/2015
2	Therapeutics 01/2021 - 01/2021
1	Thrombolytic Therapy 09/2023